Cavendish Square is a public square in the West End of London, very close to Oxford Circus, where the two main shopping thoroughfares of Oxford Street and Regent Street meet. It is located at the eastern end of Wigmore Street, which connects it to Portman Square, part of the Portman Estate, to its west. One side is faced by the rear of the flagship John Lewis shop.

One of the buildings on the square carries a blue plaque indicating that it was once the residence of Quintin Hogg, the founder of what is now the University of Westminster; the flagship building of the university backs on to Hogg's house. The Royal College of Nursing has its headquarters in Cavendish Square, and the West London Synagogue is also sited there. Near to Harley Street, the square is also noted as a site for medical practices such as those of James Paget. The artist Robert William Sievier lived on the square, and David Williams, founder of the Royal Literary Fund, ran a chapel there. Frances Fanshawe, wife of Rev. Dr. Abraham Blackborne, grandson of Richard Levett, Lord Mayor of London, died at her home on Margaret Street, Cavendish Square, in 1795 and was buried at Kew.

Cavendish Square features in Robert Louis Stevenson's novel Dr Jekyll and Mr Hyde as the home of Dr Lanyon, Jekyll's former best friend.

The bronze statue on the south side of the square (facing John Lewis) is of William George Frederick Cavendish Bentinck (1802–1848). Known simply as Lord George Bentinck, he was MP for Kings Lynn, Norfolk. The statue is by Thomas Campbell and was erected in 1848.

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